NYU Langone’s Comprehensive Epilepsy Center has a robust clinical trials program, allowing pediatric and adult patients the possibility to access new antiepileptic medications before they come to market.

Led by Jacqueline A. French, MD, and Blanca Vazquez, MD, clinical trials directors, and Claude Steriade, MD, clinical trials co-director, patients at the Comprehensive Epilepsy Center have taken part in more than 100 multicenter protocols for treating both focal and generalized epilepsy.

Patients are screened for eligibility according to each trial’s criteria. Once enrolled in a clinical trial, participants receive regular evaluation by the research staff to assess the safety and efficacy of the drug or treatment under study.

Contact Us

If you have uncontrolled seizures, are between the ages of 2 and 80, and are interested in participating in a clinical trial, please speak to your doctor or call us at 646-558-0839 to determine your eligibility for any of our ongoing trials.

Active Clinical Trials

Our investigators lead a range of clinical trials to identify new and more effective treatment options.

Autism

Understanding the Benefits of Cannabidiol in Children with Autism Spectrum Disorder
Principal investigator: Francisco X. Castellanos, MD

Cannabidivarin (CBDV) vs. Placebo in Children with Autism Spectrum Disorder (ASD)
Principal investigator: Orrin Devinsky, MD

Epilepsy

A Multicenter Double-Blind Randomized Placebo-Controlled Parallel Group Study with Open-Label Extension Phase of Lorcaserin as Adjunctive Treatment in Subjects with Dravet Syndrome
Principal investigator: Orrin Devinsky, MD

A Phase 2 Prospective Interventional Open-Label Multisite Extension Study to Assess the Long-Term Safety and Tolerability of TAK-935 (OV935) as Adjunctive Therapy in Patients with Rare Epilepsy
Principal investigator: Orrin Devinsky, MD

A Randomized Double-Blind Placebo-Controlled Multicenter Study to Evaluate the Safety Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Epilepsy
Principal investigator: Claude Steriade, MD

A Randomized Double-Blind Placebo-Controlled Parallel Group Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults with Drug-Resistant Focal-Onset Seizures (Realize Trial)
Principal investigator: Claude Steriade, MD

A Dose-Ranging Safety Tolerability and Exploratory Efficacy Study of Adjunctive EQU-001 for Seizures in Adults with Epilepsy
Principal investigator: Claude Steriade, MD

An Open-Label Study to Investigate the Safety and Pharmacokinetics of Single Ascending Doses of Antisense Oligonucleotide STK-001 in Children and Adolescents with Dravet Syndrome
Principal investigator: Orrin Devinsky, MD

Fenflurmaine in CKDL5 Deficiency Disorder (CDD)
Principal investigator: Orrin Devinsky, MD

Expanded Access Program for Lorcaserin (Belviq)
Principal investigator: Orrin Devinsky, MD

ZX008 Expanded Access Program-Dravet Syndrome
Principal investigator: Orrin Devinsky, MD

Sudden Death

Multicenter Study of Epilepsy Surgery Long-Term Outcomes Mortality
Principal investigator: Orrin Devinsky, MD

Risk Factors for Sudden Unexplained Death in Epilepsy (SUDEP)
Principal investigator: Orrin Devinsky, MD

Genetics and Precision Therapies

Study of Inherited Monogenic Disorders in Patient and Tissue-Specific Cells
Principal investigator: Orrin Devinsky, MD

Human Epilepsy Project

Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy
Principal investigator: Christopher Elder, MD

Neurotechnology and Brain Stimulation

Mechanisms and Enhancement of Learning During Sleep
Principal investigator: Anli A. Liu, MD

Neuroinflammation and Neurodegeneration

New-Onset Refractory Status Epilepticus (NORSE)
Principal investigator: Claude Steriade, MD

Gut Microbiome Alterations as a Mechanism of Immune Dysregulation in New-Onset Refractory Status Epilepticus (NORSE)
Principal investigator: Claude Steriade, MD

Prevalence and Predictors of Antineuronal Antibody Positivity in Focal Epilepsy
Principal investigator: Claude Steriade, MD

TSPO-Ligand PET Imaging in Autoimmune Epilepsy
Principal investigator: Claude Steriade, MD

Study of Inherited Monogenic Disorders in Patient and Tissue-Specific Cells
Principal investigator: Chengzu Long, PhD

Human Cognition and Neuroscience

Behavioral and Neural Correlates of Speech Production During Delayed Auditory Feedback in Subthalamic Nucleus: A Prospective Study in Parkinson’s Subjects Undergoing Deep Brain Stimulation Surgery
Principal investigator: Adeen Flinker, PhD

Neuroimaging, Human Cognition, and Neuroscience

Functional Brain Imaging in Healthy Volunteers and Epilepsy Patients to Study Cognitive Functions
Principal investigator: Biyu J. He, PhD